Drastic change of local stiffness distribution correlating to cell migration in living fibroblasts
نویسندگان
چکیده
منابع مشابه
Drastic change of local stiffness distribution correlating to cell migration in living fibroblasts.
Sequential images of the local stiffness distribution of living fibroblasts (NIH3T3) were captured under a culture condition using scanning probe microscopy in a force modulation mode. We found a clear relation between cell migration and local stiffness distribution on the cell: When cells were stationary at one position, the stiffness distribution of their cellular surface was quite stable. On...
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Cell migration, which is central to many biological processes including wound healing and cancer progression, is sensitive to environmental stiffness, and many cell types exhibit a stiffness optimum, at which migration is maximal. Here we present a cell migration simulator that predicts a stiffness optimum that can be shifted by altering the number of active molecular motors and clutches. This ...
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ژورنال
عنوان ژورنال: Cell Motility and the Cytoskeleton
سال: 2001
ISSN: 0886-1544,1097-0169
DOI: 10.1002/cm.10008